#DETUNINGS#
Basically, you have your guitar. It has at least six strings. The thinnest of these is an E, the first string, and the thickest, the sixth string, is also E. The tuning is low to high EADGBE. If you form your fingers to hold down strings at the first three or four frets, you can play a variety of major and minor chords, otherwise know as open chords. As far as I can tell, this was basically what the guitar was designed for; so you can play these chords pretty easily after a bit of practice, because most of the fingerings used are natural, and don't require you to bend your fingers in unusual or uncomfortable ways.
Lee Ranaldo playing detuned chords with his thumb
But for barre chords, non-open chords, it gets more tricky. Detuning is a way of playing simple chords like fifth chords (otherwise known as 'power chords'), and barre chords of other descriptions, without injuring your fingers. Some detuned chords can involve open strings, and these tend to sound cool.

The most common detuning, low to high, is Drop-D, DADGBE, with the low E string tuned down a step to a D. This is basically punk music in a nutshell; hold down the three low strings to make a power chord, then slide up and down to make more power chords. Even wankers like Eddie Van Halen tune their guitars into drop D.

I play chords like this using either my first or second finger holding down all three strings. With this tuning, and an amount of distortion, you can play pretty much any punk song, from the Sex Pistols to Elastica, to say nothing of pretty much everything in nu/thrash metal, and a lot of Nirvana and grunge stuff; most notably 'Bleach' and 'In Utero' are almost entirely in Drop-D, as is a lot of the Pavement back catalogue.

Drop-D is a pretty conventional tuning, and doesn't need any particular training to do it. The tunings below are not all quite so conventional. When retuning your strings, the general rule is don't tune a light gauge string (something between .010 and .013) up more than four notes, or two steps: which means you can just about risk tuning your first string up to a G, I just don't recommend it! Changing string gauges, particularly for the lighter strings, can often be a good idea, to stop them from sounding too tinny when tuned unnaturally low. Thicker strings are naturally suited for lower tunings, because they have the same tension tuned to D, for example, as a thinner gague string tuned to E.

OPEN TUNINGS AND CLOSED TUNINGS
A lot of detunings are open, rather than closed. An open tuning is one where if you can play a chord without fretting any notes: just strumming open. Closed tunings are those where strumming all six strings won't play a basic major or minor chord. Standard tuning is a closed tuning. The main advantage of open tunings is that if you fret any six or less strings together at one fret, you form a chord (usually major), or the same with a slide. So you don't necessarily have to think about the fretting of notes with your left hand so much. In standard, a D chord is played 022100, but in open D it's just 222222.

The big disadvantage with open tunings is they're very restrictive. Because most open tunings have less different notes than closed tunings, you can't play as many chords. In standard tuning, you have easy access to something like 50+ different-sounding chords, while open tunings generally have far less. Basically the simpler the tunings, the less chords you can play.

TUNING BY CHORD SHAPES
Open tunings are chords. They can be major, minor, seventh, fifth, ninth, whatever, but usually they're major. To tune a guitar to a chord shape, find out what the notes of the chord shape are. For example, E major has the three notes E, B and G# on all six strings. So if you tune your guitar to EBEG#BE, then when you strum open you play an E chord. The same approach applies to fifth (power) chords; a D power chord has the notes D and A in it: so if you tune your guitar to DADAAD, for example, when you play open you'll play a D power chord. You can make up any number of tunings by finding out which notes are in the chord, and tuning your strings to them. It's best to work from D, G, F or E chords, however, because the guitar fits best into these tunings.

STRING GAUGES
The lighter the string gauge, the higher it's tuned. The 1st and 6th strings are designed to be an octave apart, so while both are made to be tuned to the same note, one is an octave higher than the other. A set of heavy gauge strings would be more suited to a low tuning, like CGCFAD, while extra light strings can cope with unusual, higher tunings like FCFACF. If necessary, you can use different gauge strings to fit a tuning, either by swapping strings around or by starting from scratch with an uncoventional set of string gauges. One word of caution - never have your guitar tuned really high, as that will bend the neck and can damage it forever. Hawiian steel guitar uses very high tunings, but with extra-light string gauges which fit the high tuning naturally. I use medium gauge strings, which are comfortable with being tuned a few notes up or down.

TONE CLUSTERS
What makes Nick Drake probably the most interesting of all the famous guitarists is the way he used alternate tunings. In piano playing, you play a lot of weird, dischordant-sounding chords with five or more notes, called tone clusters. In standard guitar tuning, it's hard to play tone cluster chords, so Nick Drake used a variety of mysterious and often unique alternate tunings to play these chords. Generally speaking the chord shapes are still hard, as they're often barre chords and usually require all six strings. And because Nick Drake is all awkward and dead, these tunings and chords are often lost. My advice to anyone is to experiment with tone clusters and dissonant chords, because it's the only area of the guitar which hasn't been explored. Except by other folk guitarists who write songs about rivers a lot, that is.

A NOTE ON INTONATION
If you guitar has fucked-up intonation, like mine did, then chords and scales will always sound wrong. Which is all very well if you want them to sound wrong, but not when you're trying to play something, you know, in tune. So I recommend you visit this faq for advice on how to set up the intonation of yr instrument.
 
DADABE
The slacker's tuning. Tune 6th string down to D, 3rd string up to A. Hold down ADA strings to make power chord, as well as DAD strings. Used by Pavement, among others.
DADGBD
Very popular acoustic 'D' tuning. Tune 1st and 6th strings down to D.
DADGAD
Pronounced 'dadgad', this is another folk tuning. Tune down.
CGDGBD
Called Low-C, this is another folk tuning. The 6th string is tuned all the way down to C, which gives a nice contrast with the normal-sounding other strings.
DADF#AD
My favourite open D tuning, good for acoustic and slide. Tune down.
DGDGBD
The open G tuning. Chord charts for this tuning. Used by everyone who plays slide, slightly altered versions used by Sonic Youth.
DADABD
Slightly perverse Stephen Malkmus folk-style tuning. Tune 1st down to D, 3rd up and 6th down.
DGDGBE
Similar to the above. Slighter better-sounding tuning, though, I think. Just tune down the 5th and 6th strings two notes.
DGDGGG
Vaguely sitary tuning, as used by Beck on 'Black Hole'. Sounds nice just played open.
EGDGED
Tune 1st down to D. Change 2nd string to a different gauge, such as .010 and tune to an E, or alternatively just tune 2nd string down to E, but it will flap around loosely like a sitar string. Tune 5th down to G. Play power chords on GDG strings, leaving the low E string open. Used by Sonic Youth on most the of more 'rock' songs.
F#F#F#F#EB
Complete thrash tuning. Chord charts for this tuning. Tune 1st down to B, 2nd down to E (or just swap 1st and 2nd strings around). Tune 3rd down to F#, 4th up to F#, 5th down to F#, 6th up to F#. Hold down all four F#s to make a massive one-note 'chord'. Play with maximum distortion. Used on most of the really heavy SY songs.
D#G#C#F#A#D#
For those who want it, this is half-step down. Just tune every string down one note. It sounds a little lower and makes the strings a bit wobbly, but Hendrix used it almost all the time.
EG#EG#EG#
This is a pretty daft tuning. Tune all the strings down except the 6th. Hold down either the three G#s or the three Es and let the open three strings ring out. Used in SY's 'The Expressway to yr Skull'.
EBEEAB
Tune 1st down to B, 2nd down to A, 3rd down to E, 4th up to E, 5th up to A. Used by SY's Lee Ranaldo quite a bit. Power chords readily accessible by holding down low four strings, with or without open strings. For example, a nice chord would be 12-0-0-12-X-0.
EBEG#BE
The 'E' tuning. Tune 3rd up one note, and 4th and 5th up two notes to E and B. Common tuning for slide guitar, and also used by Phoebe out of 'Friends'. No, really.
CGDGBB
Pretty whacked Pavement tuning as used by Stephen Malkmus (although not Spiral Stairs). Tune 1st down to B, 5th down to G. For the 6th string you tune all the way down to a C. The middle GDG strings form a power chord.
CGCFAD
Looks weird written down, but this is yer basic nu/trash-metal tuning, as used by Slipknot et al. Tune all the strings down one step (2 notes), then tune the 6th string down an extra step. Play the same way as drop D, just with more distortion!
CGCGAA
I think this is my own invention. Open, it forms a C 6th chord without a third. Tune strings down low, low, low. Swap the 1st string for a 2nd string gauge or leave it as is for a sitary sound. Also try CCAGAA.
C#G#C#G#A#D#
This is my rock tuning, basically tune all the strings down, except for the 3rd string which goes up one note to a G#. Essentially this means you can play power chords easier.
AADGAD
Originally a folky style tuning, chords played (for example) 5-5-7-5-5-7 or simplified just 5-5-7 sound very evil. All strings tuned down, including the 6th string which is really low. Similar tuning used by Conrad Keeley out of ...Trail of Dead.
F#F#GGAA
Sonic Youth tuning, this really needs the 1st and second strings changed to a heavy gauge, or it sounds a bit odd. Tune 1st, 2nd, 4th and 5th  down, and tune the 6th string up to F#. Used a lot on the early stuff, most notably on 'Schizophrenia'.
FAEACC#
The Koto tuning, as used by Melt Banana's guitarist. Tune all strings up, except the 1st string, which you tune down to C#. AEA forms a power chord, and playing the open strings arpeggiated plays a melodic scale.
CFCFAF
Jimmy Page's tuning on 'Bron yr Aur Stomp' - an excellent F open tuning. Chord charts for this tuning. Tune all strings down to the note, except for the 1st string which goes up one semitone to F.

As a final word, although alternative tunings are great, I personally have my main guitar tuned in standard (my other guitars are currently in standard and DADGAD). I'm learning theory and all the notes and crap, and only a really good guitarist can instantly transpose scale and chord shapes into different tunings. So for the moment I'm learning this in standard. However detuning is, I think, essential for any beginner guitarist, because it allows you to build up finger strength while actually making music, rather than just fucking up everything and getting nowhere. Equally there are plenty of more strange, jazzy chords which are pretty hard/impossible to play without detuning of some form or other, plus alternative tunings also mean you can use more open strings for different chords, thus taking advantage of all the pleasant ringing qualities/ear-wrenching shrieking noises which the electric guitar is capable of producing.

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#LINKS#
Contemporary Folk Tunings
Folk might often be dull as shit, but they have a very interesting approach to music. This is a collection of some very weird, and some less weird, tunings.
Guitarists.net Alt. Tunings
A mixed bag of good, bad and obvious tunings.
Mary McCalslin
Good old Mary, whoever she is, has posted some very handy chord charts for the more commonly used alternate tunings.
Strummer Online
May the resurrection of Christ Jesus transform your life! No, really. Nowt to do with Joe Strummer, like many alternate tuning sites this is based around acoustic guitar. Chords and tips for Low C, Open G and many other nice tunings.
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